A novel functional class 2 integron in clinical Proteus mirabilis isolates

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A novel functional class 2 integron in clinical Proteus mirabilis isolates.

OBJECTIVES To describe a novel functional class 2 integron that was found in clinical Proteus mirabilis isolates. METHODS Class 1 and 2 integrons were screened by PCR in 153 clinical Proteus isolates. The variable regions of class 1 and 2 integrons were determined by restriction analysis and sequencing. The mutations of internal stop codons in class 2 integrons and their common promoters were...

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Plasmid Pattern of Biofilm Producing Proteus mirabilis and Proteus vulgaris among Clinical Isolates in Kerman University Hospitals during 2011-2012

Background & Aims: Emergence of biofilm producing Proteus strains created a serious problem in the treatment of catheter-associated urinary tract infections. The aim of this research was to study biofilm production and plasmid pattern of proteus strains associated with Urinary tract infection. Methods: A total of 88 strains of Proteus were isolated from samples collected in hospitals of Kerman/...

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Separate O-grouping schemes for serotyping clinical isolates of Proteus vulgaris and Proteus mirabilis.

Antisera were prepared against type strains of the original scheme of B. Perch (Acta Pathol. Microbiol. Scand. 25:703-714, 1948) and against newly defined types to produce separate schemes for O-grouping Proteus vulgaris and Proteus mirabilis. In assessing the schemes for their effectiveness it was found that 82% of 208 P. vulgaris isolates and 88% of 194 P. mirabilis isolates from two hospital...

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Novel rearrangement of a class 2 integron in two non-epidemiologically related isolates of Acinetobacter baumannii.

Tn7::In2-8 contains sat2-aadB-catB2(deltaattC)-dfrA1-sat2-aadA1-orfX in the variable region of a class 2 integron embedded in the Tn7-like transposon. This novel transposon was inserted in its preferred site downstream of the glms gene in Acinetobacter baumannii. Acquisition of the pseudocassette catB2 could have arisen by a secondary-site integrase-mediated intermolecular recombination event.

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Genetic characteristic of class 1 integrons in proteus mirabilis isolates from urine samples

BACKGROUND Proteus mirabilis is an opportunistic pathogen, commonly associated with complicated urinary tract infections (UTIs). UTIs caused by multidrug-resistant Proteus mirabilis have increased worldwide. Multidrug-resistance of Gram-negative enteric bacteria is usually associated with class 1 integrons. PURPOSES To investigate the prevalence and characterize gene cassettes of class 1 inte...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2013

ISSN: 1460-2091,0305-7453

DOI: 10.1093/jac/dkt456